NON SPECIFIC ENCEPHALOMYELITIS

MBP-specific experimental autoimmune encephalomyelitis in C57BL/6 mice.

کلون کردن ژن ns-ltp (non-specific lipid-transfer protein) برنج با برچسب gst به داخل باکتری اشرشیا کلی

پروتئین های ناقل لیپید (ltps) گروهی از پروتئین ها با وزن ملکولی متوسط در نزد گیاهان هستند که دارای پتانسیل های کاربردی به ویژه در سیستم های رها سازی دارو می باشند. هدف از این تحقیق، کلون کردن ژن ltp2 مربوط به گیاه برنج(oryza sativa) در وکتور بیانی pgex-6p-2، در باکتری e.coli (top10) جهت تولید پروتئین به صورت متصل با gst می باشد. از آنجائیکه ژن ltp2 در گیاه برنج را فاقد اینترون است این ژن با کمک...

Intranasal Delivery of Neural Stem Cells: A CNS-specific, Non-invasive Cell-based Therapy for Experimental Autoimmune Encephalomyelitis.

The therapeutic potential of adult neural stem cells (aNSCs) has been shown in EAE, an animal model of MS, administered by either i.c.v. or i.v. injection. However, i.c.v. is an invasive approach, while the i.v. route of aNSCs is associated with a non-specific immune suppression in the periphery. Here we demonstrate that intranasal (i.n.) delivery of fluorescently labeled aNSCs resulted in thei...

Targeting Non-classical Myelin Epitopes to Treat Experimental Autoimmune Encephalomyelitis

Qa-1 epitopes, the peptides that bind to non-classical major histocompatibility complex Ib Qa-1 molecules and are recognized by Qa-1-restricted CD8+ regulatory T (Treg) cells, have been identified in pathogenic autoimmune cells that attack myelin sheath in experimental autoimmune encephalomyelitis (EAE, an animal model for multiple sclerosis [MS]). Additionally, immunization with such epitopes ...

Specific and Non-specific Factors in Psychopharmacology

1881). These provide a wealth of detailed information about Lyell's life, though with frequent and often tantalizing gaps, but they make no attempt to trace the development of his scientific work nor to estimate it critically. They shun controversy absolutely. In 1901 T. G. Bonney of Cambridge University issued a short popular life, Charles Lyell and Modern Geology, which, despite its brevity, ...